Chris Parmelee hit a walk-off two-run homer as Minnesota stunned visiting Boston.
Andre Miller (1-1) struck out the first two batters he faced in the ninth before Kurt Suzuki reached with a sharp single through the right side. Parmelee followed and belted an 0-1 fastball out to right-center for his first home run of the season.
Eduardo Nunez added a two-run blast and Brian Dozier doubled in a pair for the Twins, who made a winner out of Glen Perkins (1-0) in relief. David Ortiz went 4-for-5 with a pair of home runs and four RBIs while Shane Victorino had three hits and drove in a run for the Red Sox.
Ortiz put Boston on top with a solo blast to right in the first but the Twins bounced right back with a five-run rally in the second as Nunez delivered a two-run homer to left, Dozier doubled in a pair and Joe Mauer delivered an RBI single. Ortiz led off the fourth and tightened it to 5-2 with another solo homer - a lined shot into the flower boxes above the wall in right-center.
Ortiz again cut the deficit to three runs with an RBI single in the sixth before the Red Sox rallied to tie it with three two-out runs in the seventh. Victorino and Ortiz each recorded an RBI single and Mike Napoli walked to load the bases before Jonny Gomes drew a walk to force in the tying run.
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GAME NOTEBOOK: Boston starter Jake Peavy was knocked around for six runs on nine hits in 4 1/3 innings while Twins starter Ricky Nolasco left with the lead after yielding three runs in six frames. ... Peavy and LHP Felix Doubront were flipped in the rotation so that Peavy could go again Sunday against the Detroit Tigers. Doubront will start Wednesday. ... Boston manager John Farrell announced that Cleveland Indians manager and former boss Terry Francona will join him on the AL staff at the All-Star Game along with Minnesota manager Ron Gardenhire.
