Denny Hamlin has done about everything in the 2021 NASCAR Cup Series season except win a race. He remedied that on Sunday night when he captured the Cook Out Southern 500 at Darlington Raceway.

That victory came at the right time, too, as it happened in the first race of the 10-race, 16-driver Playoffs. That's big as it secures the Joe Gibbs Racing driver a berth in the second round of the Playoffs.

To get the victory, Hamlin, who spent most of the season as the Cup points leader, had to hold off Kyle Larson, a five-race winner this season and the man who took the points lead from Hamlin four weeks ago.

The victory was Hamlin's fourth at the Darlington oval and 45th of his career. He led 146 laps.

Hendrick Motorsport's Larson, like Hamlin a Playoffs driver, finished second after leading 156 laps -- .2 seconds behind after taking a couple of banzai shots at Hamlin's rear bumper on the final lap.

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Ross Chastain of Chip Ganassi Racing, a non-Playoffs driver who was looking for his first-ever Cup win, was third.

Playoff contender Martin Truex, Jr. of the Gibbs team, finished fourth despite being penalized for speeding late in the race.

Fifth was contender Kevin Harvick of Stewart-Haas Racing, who was looking for his first victory of the season after winning nine a year ago.

Other Playoffs drivers who finished in the top 10 were Kurt Busch, Brad Keselowski and Joey Logano who were sixth, seventh and eighth respectively.

Four Playoffs drivers DNF'd because of wrecks.

The first of those to exit was Daytona 500 winner Michael McDowell, who got loose and slammed the wall on Lap 30.

Kyle Busch was the next Playoffs driver to head to the garages as he tangled with Austin Dillon just after start of Stage 2. Busch whacked the wall and his night was over.

"It wasn't (Dillon's) fault," the two-time Cup champion said.

William Byron of Hendrick Motorsports was next to DNF. On Lap 200, he suffered a tire problem, slammed the wall and was out of the race. He was running seventh at the time.

"We were running like Top-12," Byron said. "I think, even with all the (earlier) right rear damage and it's just terrible. I don't know, man. That sucks."

The fourth Playoff driver to crash out was Hendrick's Chase Elliott, the defending series champion. He blew a tire with 41 laps to go and pounded the wall.

Hendrick's Alex Bowman slapped the wall early in the race and never recovered. He finished the race four laps off the pace.

The second race of the three-race Round of 16 Playoffs is scheduled for next Saturday night at Richmond Raceway in Virginia.